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Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 4-Month Supply

Original price was: $51.98.Current price is: $27.99.

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Price: $51.98 - ($27.99 / Count)
(as of Apr 07, 2025 13:23:21 UTC – Details)


Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.
Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.
That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It’s easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.
Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.
For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment.
Advantage II Large Cat is a trademark of Elanco or its affiliates.
Is Discontinued By Manufacturer ‏ : ‎ No
Product Dimensions ‏ : ‎ 6.5 x 1 x 4.25 inches; 0.8 ounces
Manufacturer recommended age ‏ : ‎ 1 month and up
Item model number ‏ : ‎ 86336790
Department ‏ : ‎ Flea & Tick
Date First Available ‏ : ‎ August 3, 2004
Manufacturer ‏ : ‎ Elanco US Inc
ASIN ‏ : ‎ B004QN0MJQ
Country of Origin ‏ : ‎ Germany

Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application

Customers say

Customers find the flea treatment effective, keeping their cats flea-free and working for about two weeks. The product is affordable and easy to apply, particularly at the base of the head, and customers report their cats are much happier and show no adverse reactions. Regarding scratching resistance and adverse effects, opinions are mixed – while some report no more itching and no side effects, others mention their cats scratching more than usual and experiencing sickness. The smell receives mixed feedback, with some noting no strong odor while others find it unpleasant.

AI-generated from the text of customer reviews

8 reviews for Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 4-Month Supply

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  1. amazoncustomer

    VERY Effective!
    I recommend to flea-comb your cat at least twice a day for about a week before applying. This reduces the number of living fleas on your cat, so when you apply the product, you don’t have 300 fleas “jumping ship” so to speak. I’d gone over my cat so many times with the flea comb, I was coming up with only 1 or 2 fleas per session. Also, use a flea killing spray for areas like under beds, inside sofas, behind furniture, places fleas like to hide. Vacuum everything that you can.Proper application – First make sure your cat is comfortable with the flea comb. Then part a horizontal strip of hair about 1 inch wide at the back of the neck. While holding the part open, apply the product across this strip of exposed skin. Allow to soak for a couple seconds, then gently cover over with surrounding fur, avoiding contact with the liquid.Repeat every month for at least three months in a row to break the life cycle of the fleas, for an indoor-only cat. If your cat goes in and out of he house, it will continuously pick up fleas from outside, and I’d recommend a flea-combing every time they come back inside, and a monthly treatment with Advantage 2 for Cats. For entirely outdoor cats I recommend a flea collar like Seresto, or a monthly treatment with Advantage 2 for Cats.

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  2. Mikey M

    Good product
    Fleas be gone! Easy to used and not as expensive as other products.

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  3. C. E. Yost

    Effective
    Use this product on our cats once a month year round. No fleas or tick on them. Easy to use and effective.

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  4. INTHEYRY2013NissanGUY

    Seems to be working!!
    My cat was chewing her front legs. She’s an older cat and I’ve never seen her do this before ? So when she started this behavior I thought it was odd she was doing it underneath the chair at my dining room table and I’ve had her on a diet so I naturally thought this was her wanting more food so I’d just give her a few more oz and everything seemed to be okay till the chewing became excessive and I noticed she was losing fur on her legs so I decided to do some research and found it could be her diet ? That she developed a allergy to the food I’ve been feeding her for the past few years? I changed her food that made her happy but the chewing continued. So order these medicine for her and I haven’t noticed her chewing since and her fur is starting to grow back. She’s an older can and hasn’t had a flea problem since she was younger so this kind caught me off guard!! But it seems like advantage is working !!

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  5. TracieMahan

    Been using Advantage II for years and still happy!
    I’ve been using Advantage II for our four cats for years. The pricing and convenience of buying on Amazon are perfect for us. I keep this flea medication on our Subscribe and Save all year round. Our cats have never had a bad reaction to this flea medicine, and it’s very easy to administer to them. Our cats go outside every day, and we never see fleas. We will definitely continue to use Advantage II through Amazon Subscribe and Save for the foreseeable future!

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  6. KForbess

    READ THIS
    With my review i am going to address points from reviews posted. This review is only based on my personal experiences.1. Price. Yes, this product is expensive. However, it’s absolutely worth it. It works very well and I’ve always felt that my cats not suffering is more important than the price tag. Also, here on amazon is significantly cheaper than other places. (Saved $20 buying it here instead of 1800petmeds)2. Balding. There are a few things that need to be known for this product. Make sure you are using the appropriate dose for your cats. Weigh them. Do not assume their weight. If they are on the borderline, use the smaller dose or dont use all of the larger one. Also dont put it all in one spot. Make a line from the back of their neck to their shoulder blades.3. “Frontline is cheaper and does the same thing”. Incorrect! Frontline is cheaper but in order for frontline to work, the fleas have to bite the animals. This product does not require them to be bitten.4. “Fleas didnt go away.” You cannot expect any flea product to completely rid your home of them. It takes a minimum of 3 months to completely get rid of them if you actively fight against the fleas. You need to vacuum your floors and furniture every day at least for awhile. You also need to keep up with your laundry and wash blankets regularly, including your bedding. And its also very important to be spraying your furniture down with flea spray. RAID or Hotshot work wonders for this! Spray your furniture and bedding down every night. I also spray in the crevices of my apartment because fleas like to hide.5. “Fleas were going everywhere so i had to give them a flea bath.” Do NOT do this. Them jumping off your pets is a GOOD thing! That means the product is working. If you bathe them before the product has time to set it, you just wasted your money. This is why you need to be keeping up with prevention in your home. Theyre jumping off your animal because the product is working. Vacuuming, washing, and spraying is what will combat the infestation.You CANNOT get rid of fleas completely in a short period of time so dont expect a miracle. That’s where people get disappointed. Let the product do its job and play catch up for the next few months. And make sure you’re keeping up with the doses!!

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  7. Cheryl Calamia

    Always works.
    It always works sometimes it doesn’t last as long as you would like. Got for a great deal this time on sale. $36 is not bad for 4

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  8. MikeyJay

    Advantage II
    Stopped using as it did not work to keep the fleas off of the cats. Went to the vet for a better product. If you have only indoor cats this may be the answer to fleas.

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    Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 4-Month Supply
    Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 4-Month Supply

    Original price was: $51.98.Current price is: $27.99.

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